Pharmacological effects of whole Ganoderma (Reishi) extracts in vivo and in vitro (for references see Hobbs, 1995)
- Analgesic
- Anti-allergic activity
- Bronchitis-preventative effect, inducing regeneration of bronchial epithelium
- Anti-inflammatory
- Antibacterial, against Staphylococci, Streptococci, and Bacillus pneumoniae (perhaps due to increased immune system activity)
- Antioxidant, by eliminating hydroxyl free radicals
- Antitumor activity
- Antiviral effect, by inducing interferon production
- Lowers blood pressure
- Enhances bone marrow nucleated cell proliferation
- Cardiotonic action, lowering serum cholesterol levels with no effect on triglycerides, enhancing myocardial metabolism of hypoxic animals, and improving coronary artery hemodynamics
- Central depressant and peripheral anti-cholinergic actions on the autonomic nervous system reduce the effects of caffeine and relax muscles
- Enhanced natural killer cell (NK) activity in vitro in mice
- Expectorant and antitussive properties demonstrated in mice studies
- General immunopotentiation
- Anti-HIV activity in vitro and in vivo
- Improved adrenocortical function
- Increased production of Interleukin-1 by murine peritoneal macrophages in vitro
- Increased production of Interleukin-2 by murine splenocytes in vitro
Key active constituents:
- Beta and hetero-Beta-glucans (antitumour, immunostimulating )
- Ling Zhi-8 protein (anti-allergenic, immuno-modulating)
- Ganodermic acids triterpenes (anti-allergenic agents, cholesterol and blood pressure reducing.
